Across TCGA patient cohorts, PFN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,438 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PFN3-associated GO terms across cancer lineages are Protein insertion into ER membrane, Intracellular phosphate ion homeostasis, and tRNA thio-modification. Each is linked with PFN3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PFN3-to-partner and partner-to-PFN3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN3→partner) and Y-score (partner→PFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Protein insertion into ER membrane →	+0.043	+0.275	<.001	.002	2	9
SKCM	Intracellular phosphate ion homeostasis →	-0.059	-0.021	.001	<.001	3	6
TGCT	tRNA thio-modification →	+0.035	+0.377	.001	<.001	3	6
TGCT	Cytoplasmic sequestering of NF-kappaB →	+0.040	+0.259	<.001	<.001	3	6
STAD	Base-excision repair, AP site formation →	+0.034	+0.140	<.001	<.001	3	6
ESCA	Blood coagulation, intrinsic pathway →	+0.083	+0.197	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,438 associations by consensus.

Exploration

PFN3 survival (RNA) · tumor vs normal (RNA) · all PFN3 data types