Across TCGA cell cohorts, PFN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 361 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PFN3-associated GO terms across cancer lineages are Positive regulation of plasminogen activation, Kinin cascade, and Plasma kallikrein-kinin cascade. Each is linked with PFN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PFN3-to-partner and partner-to-PFN3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN3→partner) and Y-score (partner→PFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of plasminogen activation →	+0.190	+0.017	.003	.005	3	3
BREAST	Kinin cascade →	+0.686	+0.071	.006	<.001	3	3
BREAST	Plasma kallikrein-kinin cascade →	+0.686	+0.071	.006	<.001	3	3
BREAST	Factor XII activation →	+0.686	+0.071	.006	<.001	3	3
OVARY	Postsynaptic signal transduction →	+0.107	+0.023	.002	.005	3	2
BLOOD_Lymphoma	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.109	+0.033	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

Exploration

PFN3 survival (RNA) · tumor vs normal (RNA) · all PFN3 data types