PFN1P8

Across TCGA pan-cancer cohorts, PFN1P8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PFN1P8 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PFN1P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFN1P8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

UVM, LGG, and LUAD are the cancer types where PFN1P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.192	0.897	<.001	63	view →
LGG	OS	Tertile	All	0.735	0.881	<.001	41	view →
LUAD	DFS	Quartile	II,III,IV	0.505	0.748	.001	37	view →
UCEC	OS	Tertile	IV	0.926	0.663	.039	36	view →
READ	OS	Tertile	III,IV	0.769	0.309	.001	24	view →
STAD	OS	Quartile	IV	0.643	0.261	.009	18	view →
MESO	DFS	Quartile	II,III,IV	0.246	0.669	.010	18	view →
LUSC	OS	Quartile	III,IV	0.490	0.767	.005	17	view →
ACC	DFS	Quartile	IV	0.128	0.467	.017	15	view →
LIHC	DFS	Tertile	All	0.253	0.336	.024	15	view →
GBM	DFS	Tertile	All	0.323	0.171	.007	9	view →
COAD	DFS	Quartile	All	0.717	0.800	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PFN1P8–UVM (DFS)

Open the UVM breakdown →