PFN1P2

Across TCGA pan-cancer cohorts, PFN1P2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated PFN1P2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PFN1P2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PFN1P2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, LGG, and KIRC are the cancer types where PFN1P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.732	0.532	<.001	116	view →
LGG	DFS	Median	All	0.624	0.836	<.001	50	view →
KIRC	DFS	Tertile	All	0.756	0.839	.002	49	view →
LUSC	DFS	Tertile	II,III,IV	0.277	0.506	.004	40	view →
BRCA	OS	Tertile	III,IV	0.962	0.811	<.001	34	view →
CESC	DFS	Median	III,IV	0.211	0.743	<.001	32	view →
UCS	DFS	Quartile	II,III,IV	0.580	0.186	.001	24	view →
SKCM	OS	Quartile	III,IV	0.615	0.274	.003	22	view →
COAD	DFS	Median	All	0.729	0.828	.001	22	view →
THYM	OS	Quartile	II,III,IV	0.672	1.000	.006	9	view →
TGCT	DFS	Median	All	0.901	0.759	.040	6	view →
ACC	OS	Tertile	II,III,IV	0.896	0.466	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

PFN1P2–HNSC (DFS)

Open the HNSC breakdown →