PFN1

Across TCGA pan-cancer cohorts, PFN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PFN1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher PFN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PFN1 expression acts as an unfavorable survival marker.

DLBC, BLCA, and ESCA are the cancer types where PFN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
BLCA	OS	Median	IV	0.120	0.599	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PFN1–DLBC (OS)

Open the DLBC breakdown →