PFN1

Across TCGA pan-cancer cohorts, PFN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PFN1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PFN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

COAD, PDAC, and GBM are the cancer types where PFN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.875	1.000	.015	48	view →
PDAC	OS	Median	II,III,IV	0.510	0.246	.006	23	view →
GBM	OS	Quartile	All	0.315	0.655	.001	10	view →
OV	DFS	Median	All	0.869	1.000	.036	4	view →
HNSC	DFS	Median	All	0.920	0.984	.044	2	view →
LUAD	OS	Median	III,IV	0.222	0.627	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PFN1–COAD (DFS)

Open the COAD breakdown →