PFN1

Across TCGA patient cohorts, PFN1 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFN1-associated genes across cancer lineages are PSAT1P4, MIR6075, and RN7SKP230. Each is linked with PFN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFN1-to-partner and partner-to-PFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by PFN1-low versus PFN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN1→partner) and Y-score (partner→PFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSAT1P4 →	+0.170	+2.563	.009	.009	3	2
UCEC	MIR6075 →	+0.400	+3.316	<.001	.002	3	1
UCEC	RN7SKP230 →	+0.384	+2.799	.003	.007	3	1
UCEC	SNORA36C →	+0.292	+3.551	<.001	.004	3	1
UCEC	SNORD116-29 →	+0.493	+3.203	<.001	.003	3	1
UCEC	IGHD2-15 →	+1.987	+3.342	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PSAT1P4 by PFN1 expression — UCEC

Explore this box plot interactively →