PFN1

Across TCGA patient cohorts, PFN1 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFN1-associated genes across cancer lineages are Mesangial cells, Erythrocytes, and pDC. Each is linked with PFN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFN1-to-partner and partner-to-PFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesangial cells grouped by PFN1-low versus PFN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN1→partner) and Y-score (partner→PFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mesangial cells →	-0.057	-2.983	.010	.036	3	1
UCEC	Erythrocytes →	+0.044	+3.000	.001	.037	2	1
UCEC	pDC →	+0.070	+2.815	.012	.036	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Mesangial cells by PFN1 expression — UCEC

Explore this box plot interactively →