PFN1

Across TCGA cell cohorts, PFN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,565 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PFN1-associated GO terms across cancer lineages are Protein depolymerization, Pyrimidine nucleotide biosynthetic process, and Protein localization to microtubule plus-end. Each is linked with PFN1 in more than 15 cancer types. Because this analysis shows association rather than direction, both PFN1-to-partner and partner-to-PFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by PFN1-low versus PFN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN1→partner) and Y-score (partner→PFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein depolymerization →	+0.152	+1.650	<.001	<.001	3	16
URINARY_TRACT	Pyrimidine nucleotide biosynthetic process →	+0.090	+1.302	.002	<.001	3	13
BONE	Protein localization to microtubule plus-end →	+0.209	+1.141	<.001	<.001	3	12
BONE	Protein localization to microtubule end →	+0.209	+1.141	<.001	<.001	3	12
PANCREAS	XMP metabolic process →	+0.163	+0.913	<.001	<.001	3	12
PANCREAS	XMP biosynthetic process →	+0.163	+0.913	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,565 associations by consensus.

Protein depolymerization by PFN1 expression — BONE

Explore this box plot interactively →