PFKP

Across TCGA pan-cancer cohorts, PFKP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PFKP data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PFKP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PFKP expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and COAD are the cancer types where PFKP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.603	0.920	<.001	55	view →
HNSC	OS	Median	IV	0.865	0.601	.006	21	view →
COAD	DFS	Tertile	II,III,IV	0.897	1.000	.017	12	view →
PDAC	DFS	Median	III,IV	0.450	0.876	.016	8	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	6	view →
UCEC	OS	Median	All	0.981	0.917	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PFKP–LUAD (OS)

Open the LUAD breakdown →