PFKP

Across TCGA patient cohorts, PFKP mutation is significantly associated with the RNA expression of many other genes, with 5,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKP-associated genes across cancer lineages are RN7SL499P, RNU6-249P, and FCGR1CP. Each is linked with PFKP in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKP-to-partner and partner-to-PFKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL499P grouped by PFKP-low versus PFKP-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKP→partner) and Y-score (partner→PFKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL499P →	+0.154	+4.070	.005	.004	3	2
HNSC	RNU6-249P →	+0.688	+4.654	<.001	.004	3	2
UCEC	FCGR1CP →	+0.322	+1.587	<.001	.007	3	2
COAD	LINC01775 →	+0.361	+2.820	.009	.001	3	2
UCEC	MIA-RAB4B →	+0.044	+1.541	<.001	<.001	3	2
UCEC	LINC01943 →	+0.363	+1.660	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,231 associations by consensus.

RN7SL499P by PFKP expression — LUSC

Explore this box plot interactively →