PFKP

Across TCGA patient cohorts, PFKP mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKP-associated genes across cancer lineages are eIF4E, Akt_pT308, and PRAS40_pT246. Each is linked with PFKP in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKP-to-partner and partner-to-PFKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PFKP-low versus PFKP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKP→partner) and Y-score (partner→PFKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.191	+2.820	.001	.001	3	2
UCEC	Akt_pT308 →	+0.421	+1.584	.020	.015	3	2
UCEC	PRAS40_pT246 →	+0.110	+1.183	.025	.011	3	2
UCEC	Annexin-1 →	+0.429	+1.867	.004	.004	3	2
UCEC	ATM →	-0.349	-1.986	.007	.008	3	2
UCEC	Beclin →	-0.069	-1.765	.011	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eIF4E by PFKP expression — UCEC

Explore this box plot interactively →