PFKP

Across TCGA cell cohorts, PFKP mutation is significantly associated with the RNA expression of many other genes, with 411 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PFKP-associated genes across cancer lineages are PHF5A, CCNA2, and TYSND1. Each is linked with PFKP in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKP-to-partner and partner-to-PFKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by PFKP-low versus PFKP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKP→partner) and Y-score (partner→PFKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHF5A →	+0.502	+2.850	.001	<.001	3	2
LARGE_INTESTINE	CCNA2 →	+0.579	+2.244	.006	.003	3	2
LARGE_INTESTINE	TYSND1 →	+0.525	+2.158	.006	.004	3	2
LARGE_INTESTINE	PWWP3A →	+0.570	+2.850	.005	<.001	3	2
LARGE_INTESTINE	SMCO4 →	+0.653	+2.244	.007	.003	3	2
LARGE_INTESTINE	ALG6 →	+0.446	+3.459	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 411 associations by consensus.

PHF5A by PFKP expression — LARGE_INTESTINE

Explore this box plot interactively →