PFKM

Across TCGA pan-cancer cohorts, PFKM Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PFKM data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PFKM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PFKM expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

THYM, HNSC, and LUSC are the cancer types where PFKM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	DFS	Median	All	0.119	0.712	<.001	42	view →
LUSC	DFS	Median	III,IV	0.079	0.658	<.001	12	view →
SCLC	OS	Median	All	0.055	0.708	<.001	12	view →
LUAD	OS	Median	All	0.237	0.788	.008	9	view →
PCPG	DFS	Median	All	0.229	0.822	.024	6	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
UCEC	DFS	Median	All	0.952	0.828	.030	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
GBM	DFS	Median	All	1.000	0.193	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PFKM–THYM (OS)

Open the THYM breakdown →