PFKM

Across TCGA pan-cancer cohorts, PFKM mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PFKM data layer compared with 21 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PFKM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFKM expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where PFKM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.362	1.000	.002	46	view →
PDAC	DFS	Tertile	All	0.899	0.572	.001	40	view →
HNSC	OS	Tertile	II,III,IV	0.941	1.000	.031	2	view →
GBM	DFS	Median	All	0.808	0.694	.030	1	view →
LSCC	OS	Quartile	All	1.000	0.889	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PFKM–UCEC (DFS)

Open the UCEC breakdown →