PFKFB3

Across TCGA patient cohorts, PFKFB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,665 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PFKFB3-associated proteins across cancer lineages are SCAF1_S548, SRRM2_T1043, and CP. Each is linked with PFKFB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PFKFB3-to-partner and partner-to-PFKFB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB3 versus SCAF1_S548 in UCEC, with a Pearson correlation of -0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB3→partner) and Y-score (partner→PFKFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCAF1_S548 →	-0.364	-0.754	.003	.004	3	4
HNSC	SRRM2_T1043 →	-0.746	-0.468	.003	.002	3	4
COAD	CP →	+0.673	+0.849	.001	<.001	3	4
GBM	DNAJC13 →	+0.223	+0.553	.002	.001	3	4
BRCA	GBE1 →	+0.290	+0.759	.002	.006	2	5
COAD	GCA →	+0.513	+0.609	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,665 associations by consensus.

PFKFB3 vs SCAF1_S548 — UCEC

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