PFKFB3

Across TCGA patient cohorts, PFKFB3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,878 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PFKFB3-associated genes across cancer lineages are TREM1, LINC02656, and AQP9. Each is linked with PFKFB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PFKFB3-to-partner and partner-to-PFKFB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB3 versus TREM1 in GBM, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB3→partner) and Y-score (partner→PFKFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TREM1 →	+1.196	+0.210	.001	.001	3	5
UCEC	LINC02656 →	+0.838	+0.398	<.001	<.001	3	5
GBM	AQP9 →	+1.243	+0.279	.001	<.001	3	5
HNSC	PPIF →	+0.710	+0.209	.005	.001	3	5
HNSC	ABCA8 →	-1.012	-0.310	<.001	<.001	3	5
HNSC	TUBA1C →	+0.677	+0.298	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,878 associations by consensus.

PFKFB3 vs TREM1 — GBM

Explore this scatter interactively →