PFKFB3

Across TCGA patient cohorts, PFKFB3 mutation is significantly associated with the RNA expression of many other genes, with 2,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB3-associated genes across cancer lineages are RN7SL275P, ATP6V0D1, and SNRNP25. Each is linked with PFKFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB3-to-partner and partner-to-PFKFB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL275P grouped by PFKFB3-low versus PFKFB3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB3→partner) and Y-score (partner→PFKFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RN7SL275P →	+0.138	+5.305	<.001	.003	3	2
UCEC	ATP6V0D1 →	+0.419	+1.443	.004	.003	3	2
UCEC	SNRNP25 →	+0.413	+2.174	<.001	<.001	3	2
UCEC	RNF25 →	+0.278	+2.141	<.001	.002	3	2
UCEC	MON1A →	+0.300	+2.513	<.001	<.001	3	2
UCEC	CDT1 →	+0.750	+4.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

RN7SL275P by PFKFB3 expression — LIHC

Explore this box plot interactively →