PFKFB3

Across TCGA patient cohorts, PFKFB3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB3-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FoxM1. Each is linked with PFKFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB3-to-partner and partner-to-PFKFB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PFKFB3-low versus PFKFB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB3→partner) and Y-score (partner→PFKFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.300	+1.392	.010	.019	3	2
UCEC	A-Raf_pS299 →	-0.154	-2.000	<.001	.009	3	2
UCEC	FoxM1 →	+0.171	+1.392	.045	.019	3	2
UCEC	INPP4B →	-0.218	-1.638	.041	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.132	-1.638	.017	.006	3	2
UCEC	ATM →	-0.615	-3.986	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eEF2 by PFKFB3 expression — UCEC

Explore this box plot interactively →