PFKFB3

Across TCGA cell cohorts, PFKFB3 mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PFKFB3-associated genes across cancer lineages are SB216763, Leflunomide, and SGC-CBP30. Each is linked with PFKFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB3-to-partner and partner-to-PFKFB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SB216763 grouped by PFKFB3-low versus PFKFB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB3→partner) and Y-score (partner→PFKFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SB216763 →	+0.486	+2.646	.046	.047	3	1
LARGE_INTESTINE	Leflunomide →	+0.294	+2.769	.021	.040	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.332	+2.649	.018	.046	3	1
LARGE_INTESTINE	BDF00022089a →	+0.313	+2.649	.044	.046	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.587	+2.649	.024	.046	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.582	+2.678	.027	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

SB216763 by PFKFB3 expression — LARGE_INTESTINE

Explore this box plot interactively →