PFKFB1

Across TCGA patient cohorts, PFKFB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,196 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PFKFB1-associated proteins across cancer lineages are GTF3C4, COPRS_S66, and DSG2. Each is linked with PFKFB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB1 versus GTF3C4 in LSCC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF3C4 →	+0.353	+0.524	<.001	<.001	3	4
LSCC	COPRS_S66 →	+0.555	+0.439	.001	.001	3	3
OV	DSG2 →	-0.380	-0.361	.001	<.001	3	3
OV	FABP4 →	+1.847	+0.638	<.001	<.001	3	3
LSCC	RPRD2_S928 →	+0.282	+0.370	.002	<.001	3	3
GBM	RRAS →	-0.475	-0.383	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,196 associations by consensus.

PFKFB1 vs GTF3C4 — LSCC

Explore this scatter interactively →