PFKFB1

Across TCGA patient cohorts, PFKFB1 protein abundance is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PFKFB1-associated genes across cancer lineages are FSCN3, CLIP4, and CCDC59. Each is linked with PFKFB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB1 versus FSCN3 in HNSC, with a Pearson correlation of -0.84.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FSCN3 →	-0.211	-1.343	.007	.003	3	1
HNSC	CLIP4 →	-1.002	-1.150	<.001	.003	3	1
HNSC	CCDC59 →	-0.310	-1.476	.001	<.001	3	1
HNSC	PDGFRA →	+0.956	+1.476	.002	<.001	3	1
HNSC	KLB →	-0.875	-1.789	.002	.002	3	1
HNSC	RPS6KC1 →	-0.708	-1.476	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

PFKFB1 vs FSCN3 — HNSC

Explore this scatter interactively →