PFKFB1

Across TCGA patient cohorts, PFKFB1 mutation is significantly associated with the RNA expression of many other genes, with 2,404 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB1-associated genes across cancer lineages are RNA5SP411, RN7SL122P, and RNU6-618P. Each is linked with PFKFB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by PFKFB1-low versus PFKFB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.713	+1.461	.001	.009	3	3
LIHC	RN7SL122P →	+0.217	+4.878	<.001	.005	3	3
UCEC	RNU6-618P →	+0.233	+2.452	<.001	<.001	3	3
GBM	RN7SL229P →	+0.339	+5.584	<.001	.003	3	2
GBM	RN7SL810P →	+0.508	+4.969	<.001	.009	3	2
UCEC	H3C8 →	+0.475	+2.178	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

RNA5SP411 by PFKFB1 expression — UCEC

Explore this box plot interactively →