PFKFB1

Across TCGA patient cohorts, PFKFB1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB1-associated genes across cancer lineages are ASNS, NF2, and Annexin_VII. Each is linked with PFKFB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PFKFB1-low versus PFKFB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.304	+1.700	.017	.042	3	3
COAD	NF2 →	+0.231	+2.815	.030	.036	3	2
SKCM	Annexin_VII →	+0.189	+2.321	.011	.035	3	2
UCEC	14-3-3_beta →	-0.071	-1.847	.044	.049	3	2
UCEC	ERK2 →	+0.145	+1.362	.033	.037	3	2
UCEC	JNK_pT183_Y185 →	-0.187	-2.415	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by PFKFB1 expression — UCEC

Explore this box plot interactively →