PFKFB1

Across TCGA cell cohorts, PFKFB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,907 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PFKFB1-associated GO terms across cancer lineages are Sperm motility, Flagellated sperm motility, and Golgi vesicle transport. Each is linked with PFKFB1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sperm motility grouped by PFKFB1-low versus PFKFB1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Sperm motility →	-0.082	-0.262	<.001	.003	3	10
LUNG_SCLC	Flagellated sperm motility →	-0.082	-0.262	<.001	.003	3	10
LUNG_SCLC	Golgi vesicle transport →	+0.043	+0.277	.003	<.001	3	9
OVARY	Nucleic acid catabolic process →	+0.040	+0.174	<.001	<.001	3	8
URINARY_TRACT	Regulation of myoblast fusion →	+0.110	+0.298	<.001	.002	3	8
STOMACH	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.140	+0.258	.004	.005	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,907 associations by consensus.

Sperm motility by PFKFB1 expression — LUNG_SCLC

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