PFKFB1

Across TCGA cell cohorts, PFKFB1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PFKFB1-associated genes across cancer lineages are CSN2, SPINK9, and OR1L3. Each is linked with PFKFB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB1-to-partner and partner-to-PFKFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by PFKFB1-low versus PFKFB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB1→partner) and Y-score (partner→PFKFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.078	+4.415	<.001	.007	3	2
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	2
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	OR5A1 →	+0.015	+5.022	<.001	.002	3	1
SKIN	ZNF479 →	+0.287	+4.467	<.001	.004	3	1
SKIN	GLRA4 →	+0.024	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CSN2 by PFKFB1 expression — SKIN

Explore this box plot interactively →