PFDN5

Across TCGA pan-cancer cohorts, PFDN5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PFDN5 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PFDN5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PFDN5 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

BRCA, LIHC, and KICH are the cancer types where PFDN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.928	0.876	<.001	98	view →
LIHC	DFS	Tertile	All	0.430	0.620	<.001	78	view →
KICH	DFS	Quartile	II,III,IV	0.277	1.000	.001	57	view →
ACC	DFS	Tertile	All	0.232	0.641	.001	53	view →
UCS	OS	Median	IV	0.404	0.752	.013	30	view →
PAAD	OS	Quartile	All	0.616	0.263	.013	18	view →
PRAD	DFS	Median	All	0.691	0.874	<.001	18	view →
UCEC	OS	Tertile	III,IV	0.636	0.348	.032	14	view →
THCA	DFS	Median	All	0.913	0.775	.002	13	view →
BLCA	DFS	Tertile	All	0.584	0.435	.019	12	view →
CHOL	DFS	Tertile	III,IV	0.779	0.162	.024	12	view →
LUSC	DFS	Median	II,III,IV	0.630	0.781	.003	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PFDN5–BRCA (DFS)

Open the BRCA breakdown →