PFDN4

Across TCGA pan-cancer cohorts, PFDN4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PFDN4 data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PFDN4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFDN4 expression acts as an unfavorable survival marker.

CESC, STAD, and SKCM are the cancer types where PFDN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.140	0.823	<.001	24	view →
STAD	OS	Median	All	0.184	0.730	.001	18	view →
SKCM	OS	Median	All	0.202	0.787	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	All	0.600	0.872	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PFDN4–CESC (DFS)

Open the CESC breakdown →