PFDN4

Across TCGA pan-cancer cohorts, PFDN4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PFDN4 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PFDN4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFDN4 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where PFDN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.291	1.000	.001	49	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	OS	Tertile	All	0.766	0.911	.024	5	view →
LSCC	OS	Tertile	III,IV	0.861	1.000	.045	3	view →
LUAD	OS	Median	All	0.719	0.933	.044	2	view →
GBM	OS	Quartile	All	0.963	0.761	.047	1	view →
PDAC	OS	Median	II,III,IV	0.927	0.781	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PFDN4–HNSC (DFS)

Open the HNSC breakdown →