PFDN4

Across TCGA cell cohorts, PFDN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,729 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PFDN4-associated GO terms across cancer lineages are tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, Positive regulation of ligase activity, and Pre-mRNA catabolic process. Each is linked with PFDN4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PFDN4-to-partner and partner-to-PFDN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation grouped by PFDN4-low versus PFDN4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFDN4→partner) and Y-score (partner→PFDN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.123	+0.768	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of ligase activity →	+0.112	+0.815	<.001	.002	3	9
KIDNEY	Pre-mRNA catabolic process →	-0.128	-0.669	<.001	.003	3	9
LUNG_NSCLC_LUAD	Protein histidyl modification to diphthamide →	+0.071	+0.653	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Peptidyl-histidine modification →	+0.071	+0.653	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of protein transport →	-0.056	-0.605	.003	.005	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,729 associations by consensus.

tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation by PFDN4 expression — LARGE_INTESTINE

Explore this box plot interactively →