PFDN2

Across TCGA cell cohorts, PFDN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,998 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PFDN2-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, rRNA processing, and Threonyl-tRNA aminoacylation. Each is linked with PFDN2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PFDN2-to-partner and partner-to-PFDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by PFDN2-low versus PFDN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFDN2→partner) and Y-score (partner→PFDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.111	+0.696	.001	<.001	3	11
BONE	rRNA processing →	+0.121	+0.619	<.001	.005	3	10
LUNG_NSCLC_LUSC	Threonyl-tRNA aminoacylation →	+0.201	+0.788	.008	.004	3	10
URINARY_TRACT	Nuclear polyadenylation-dependent rRNA catabolic process →	+0.096	+0.894	.001	<.001	3	9
URINARY_TRACT	TRAMP-dependent tRNA surveillance pathway →	+0.096	+0.894	.001	<.001	3	9
CNS	U4 snRNA 3'-end processing →	+0.129	+0.801	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,998 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by PFDN2 expression — BONE

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