PFDN1

Across TCGA pan-cancer cohorts, PFDN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PFDN1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PFDN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PFDN1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where PFDN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.510	1.000	.002	28	view →
PDAC	DFS	Quartile	III,IV	0.955	0.376	.008	21	view →
LUAD	OS	Median	II,III,IV	0.537	0.883	.010	17	view →
CCRCC	DFS	Quartile	All	0.539	0.879	.002	9	view →
GBM	DFS	Median	All	0.882	0.615	<.001	8	view →
HNSC	DFS	Tertile	III,IV	1.000	0.905	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PFDN1–LSCC (DFS)

Open the LSCC breakdown →