PFAS

Across TCGA pan-cancer cohorts, PFAS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PFAS data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PFAS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PFAS expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where PFAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.850	0.515	.003	45	view →
PDAC	OS	Quartile	II,III,IV	0.317	0.705	.001	7	view →
LSCC	OS	Median	II,III,IV	0.862	0.595	.012	7	view →
UCEC	OS	Tertile	All	0.885	1.000	.030	2	view →
GBM	OS	Median	All	0.587	0.466	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PFAS–CCRCC (DFS)

Open the CCRCC breakdown →