PFAS

Across TCGA patient cohorts, PFAS protein abundance is significantly associated with the RNA expression of many other genes, with 11,903 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PFAS-associated genes across cancer lineages are WRAP53, SCO1, and TSR1. Each is linked with PFAS in more than 7 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFAS versus WRAP53 in OV, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WRAP53 →	+0.733	+0.358	<.001	<.001	3	8
HNSC	SCO1 →	+0.418	+0.260	.003	<.001	3	6
COAD	TSR1 →	+0.572	+0.362	.001	.002	3	6
OV	ELP5 →	+0.576	+0.336	<.001	<.001	3	6
COAD	MRM3 →	+0.515	+0.434	<.001	<.001	3	6
OV	C1QBP →	+0.700	+0.339	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,903 associations by consensus.

PFAS vs WRAP53 — OV

Explore this scatter interactively →