PFAS

Across TCGA patient cohorts, PFAS mutation is significantly associated with the RNA expression of many other genes, with 3,987 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFAS-associated genes across cancer lineages are SLC25A4, SAP30, and H3P16. Each is linked with PFAS in more than 2 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A4 grouped by PFAS-low versus PFAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A4 →	+0.547	+1.551	<.001	<.001	3	3
UCEC	SAP30 →	+0.580	+1.938	<.001	<.001	3	3
UCEC	H3P16 →	+0.521	+1.379	.004	.002	3	3
HNSC	RNU1-35P →	+0.267	+3.771	<.001	<.001	3	3
UCEC	GOT1 →	+0.376	+1.981	<.001	<.001	3	3
UCEC	TNFSF10 →	-0.755	-1.574	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,987 associations by consensus.

SLC25A4 by PFAS expression — UCEC

Explore this box plot interactively →