PFAS

Across TCGA patient cohorts, PFAS mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFAS-associated genes across cancer lineages are MEK1, Shc_pY317, and 4E-BP1. Each is linked with PFAS in more than 3 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PFAS-low versus PFAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.313	+1.643	.004	.002	3	4
UCEC	Shc_pY317 →	-0.132	-1.247	.003	.041	3	3
UCEC	4E-BP1 →	+0.227	+2.117	.005	.002	3	3
UCEC	eEF2 →	+0.272	+1.906	.011	.014	3	2
UCEC	PCNA →	+0.171	+2.169	.008	.003	3	2
UCEC	PDCD4 →	-0.426	-2.321	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MEK1 by PFAS expression — UCEC

Explore this box plot interactively →