PFAS

Across TCGA cell cohorts, PFAS RNA expression is significantly associated with the RNA expression of many other genes, with 12,024 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PFAS-associated genes across cancer lineages are GEMIN4, SENP3, and AURKB. Each is linked with PFAS in more than 19 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFAS versus GEMIN4 in BLOOD_Myeloma, with a Pearson correlation of 0.79.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GEMIN4 →	+1.543	+1.637	<.001	<.001	3	20
BLOOD_Lymphoma	SENP3 →	+0.977	+1.446	<.001	<.001	3	20
URINARY_TRACT	AURKB →	+1.827	+1.791	<.001	<.001	3	19
BLOOD_Lymphoma	CLUH →	+1.738	+1.614	<.001	<.001	3	19
BLOOD_Myeloma	SCO1 →	+1.268	+1.087	<.001	.003	2	20
BLOOD_Lymphoma	TSR1 →	+1.203	+1.509	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,024 associations by consensus.

PFAS vs GEMIN4 — BLOOD_Myeloma

Explore this scatter interactively →