PFAS

Across TCGA cell cohorts, PFAS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,536 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PFAS-associated GO terms across cancer lineages are IMP biosynthetic process, 'de novo' IMP biosynthetic process, and 'de novo' AMP biosynthetic process. Each is linked with PFAS in more than 19 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP biosynthetic process grouped by PFAS-low versus PFAS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IMP biosynthetic process →	+0.205	+1.445	<.001	<.001	3	20
OESOPHAGUS	'de novo' IMP biosynthetic process →	+0.202	+1.268	.007	.002	3	20
LIVER	'de novo' AMP biosynthetic process →	+0.183	+1.304	.001	<.001	3	20
OESOPHAGUS	XMP metabolic process →	+0.199	+1.387	.006	<.001	2	20
OESOPHAGUS	XMP biosynthetic process →	+0.199	+1.387	.006	<.001	2	20
OESOPHAGUS	'de novo' XMP biosynthetic process →	+0.199	+1.387	.006	<.001	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,536 associations by consensus.

IMP biosynthetic process by PFAS expression — OESOPHAGUS

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