PFAS

Across TCGA cell cohorts, PFAS mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PFAS-associated genes across cancer lineages are HSD17B4, ELP2, and NANOGNB. Each is linked with PFAS in more than 1 cancer types. Because this analysis shows association rather than direction, both PFAS-to-partner and partner-to-PFAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B4 grouped by PFAS-low versus PFAS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFAS→partner) and Y-score (partner→PFAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HSD17B4 →	+0.387	+3.087	.007	.006	3	2
LARGE_INTESTINE	ELP2 →	+0.686	+3.212	.002	.006	3	2
SOFT_TISSUE	NANOGNB →	+0.025	+4.369	.001	.008	3	1
STOMACH	ASB17 →	+0.028	+3.432	<.001	.008	3	1
STOMACH	HSFX3 →	+0.074	+3.857	<.001	.004	3	1
BLOOD_Leukemia	BTBD16 →	+0.092	+4.281	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

HSD17B4 by PFAS expression — SKIN

Explore this box plot interactively →