PF4

Across TCGA pan-cancer cohorts, PF4 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PF4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PF4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PF4 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and COAD are the cancer types where PF4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PF4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−2.361	<.001	9	view →
LUAD	Female	III,IV	−2.218	<.001	9	view →
COAD	Female	All	−0.755	<.001	9	view →
HNSC	Male	IV	−1.283	<.001	8	view →
OV	All	All	−1.503	.022	2	view →
CCRCC	Female	III,IV	−0.447	.025	2	view →
PDAC	Male	IV	−2.710	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PF4–LSCC

Open the LSCC breakdown →