PEX6

Across TCGA pan-cancer cohorts, PEX6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PEX6 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PEX6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PEX6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where PEX6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.939	0.721	.008	17	view →
LSCC	DFS	Median	All	0.989	0.886	.003	14	view →
UCEC	DFS	Median	All	0.974	0.833	.003	10	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	10	view →
HNSC	DFS	Quartile	IV	0.527	0.797	.031	3	view →
PDAC	DFS	Median	II,III,IV	0.688	0.791	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PEX6–CCRCC (OS)

Open the CCRCC breakdown →