PEX6

Across TCGA patient cohorts, PEX6 mutation is significantly associated with the RNA expression of many other genes, with 1,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX6-associated genes across cancer lineages are MIR4641, CENPU, and AP1S3. Each is linked with PEX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PEX6-to-partner and partner-to-PEX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4641 grouped by PEX6-low versus PEX6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX6→partner) and Y-score (partner→PEX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4641 →	+0.378	+3.240	.004	.005	3	3
UCEC	CENPU →	+0.608	+3.700	.007	.001	3	2
UCEC	AP1S3 →	+0.656	+3.700	<.001	.001	3	2
UCEC	TXNDC11 →	+0.433	+2.724	<.001	.003	3	2
UCEC	CD8A →	+1.121	+2.606	<.001	<.001	3	2
UCEC	DPEP1 →	-1.139	-3.799	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,315 associations by consensus.

MIR4641 by PEX6 expression — SKCM

Explore this box plot interactively →