PEX6

Across TCGA patient cohorts, PEX6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX6-associated genes across cancer lineages are MEK1, ATM, and Notch1. Each is linked with PEX6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PEX6-to-partner and partner-to-PEX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PEX6-low versus PEX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX6→partner) and Y-score (partner→PEX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.449	+2.459	.002	.019	3	4
UCEC	ATM →	-0.486	-2.308	.009	.033	3	3
UCEC	Notch1 →	+0.239	+2.125	<.001	.010	3	2
UCEC	Annexin-1 →	+0.758	+1.894	<.001	.030	3	2
UCEC	Chk2_pT68 →	-0.153	-2.312	.047	.034	3	2
UCEC	eIF4G →	+0.297	+2.999	.020	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by PEX6 expression — UCEC

Explore this box plot interactively →