PEX6

Across TCGA cell cohorts, PEX6 mutation is significantly associated with the RNA expression of many other genes, with 692 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX6-associated genes across cancer lineages are TMEM241, EAF1, and TMEM267. Each is linked with PEX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX6-to-partner and partner-to-PEX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM241 grouped by PEX6-low versus PEX6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX6→partner) and Y-score (partner→PEX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM241 →	+0.630	+3.169	.001	.009	3	2
BLOOD_Leukemia	EAF1 →	+0.629	+3.199	<.001	.007	3	2
BLOOD_Leukemia	TMEM267 →	+0.579	+3.199	.003	.007	3	2
LARGE_INTESTINE	DTWD2 →	+0.680	+2.502	<.001	.005	3	2
LARGE_INTESTINE	PRR14L →	+0.666	+3.628	.001	<.001	3	2
SKIN	MEIKIN →	+0.017	+4.415	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 692 associations by consensus.

TMEM241 by PEX6 expression — LARGE_INTESTINE

Explore this box plot interactively →