PEX3

Across TCGA pan-cancer cohorts, PEX3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PEX3 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PEX3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PEX3 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

CCRCC, LUAD, and COAD are the cancer types where PEX3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.687	0.883	.016	15	view →
LUAD	DFS	Quartile	All	0.670	1.000	.017	7	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
PDAC	DFS	Tertile	All	0.300	0.555	.010	5	view →
HNSC	DFS	Tertile	III,IV	0.892	1.000	.018	3	view →
GBM	DFS	Tertile	All	0.762	0.621	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PEX3–CCRCC (OS)

Open the CCRCC breakdown →