PEX3

Across TCGA pan-cancer cohorts, PEX3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PEX3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PEX3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PEX3 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, LUAD, and CCRCC are the cancer types where PEX3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEX3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.233	<.001	8	view →
LUAD	Female	II,III,IV	+0.291	<.001	7	view →
CCRCC	Male	All	−0.334	<.001	6	view →
LSCC	Male	All	+0.163	<.001	6	view →
PDAC	Female	All	+0.358	.001	4	view →
HNSC	All	All	+0.120	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PEX3–COAD

Open the COAD breakdown →