PEX3

Across TCGA patient cohorts, PEX3 mutation is significantly associated with the RNA expression of many other genes, with 1,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX3-associated genes across cancer lineages are RN7SL135P, GAPDHP56, and TPTE. Each is linked with PEX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX3-to-partner and partner-to-PEX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL135P grouped by PEX3-low versus PEX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX3→partner) and Y-score (partner→PEX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL135P →	+0.457	+6.547	<.001	.001	3	2
COAD	GAPDHP56 →	+0.182	+5.017	<.001	.009	3	2
BRCA	TPTE →	+0.661	+4.373	<.001	.007	3	1
BRCA	RNU6-928P →	+0.306	+4.841	.001	.006	3	1
BRCA	LINC02444 →	+0.297	+4.220	<.001	.009	3	1
UCEC	RN7SL134P →	+0.178	+2.599	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,177 associations by consensus.

RN7SL135P by PEX3 expression — COAD

Explore this box plot interactively →