PEX3

Across TCGA patient cohorts, PEX3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX3-associated genes across cancer lineages are eEF2, Gab2, and GATA6. Each is linked with PEX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX3-to-partner and partner-to-PEX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PEX3-low versus PEX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX3→partner) and Y-score (partner→PEX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.462	+3.000	.007	.036	3	1
UCEC	Gab2 →	+0.446	+2.459	.009	.020	3	1
UCEC	GATA6 →	-0.220	-2.459	.003	.019	3	1
UCEC	INPP4B →	-0.332	-2.321	.033	.034	3	1
UCEC	JNK2 →	+0.308	+3.009	.001	.019	3	1
UCEC	Ku80 →	+0.303	+2.472	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by PEX3 expression — UCEC

Explore this box plot interactively →