PEX3

Across TCGA cell cohorts, PEX3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX3-associated genes across cancer lineages are OR56A1, SLC15A5, and KRTAP2-1. Each is linked with PEX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX3-to-partner and partner-to-PEX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A1 grouped by PEX3-low versus PEX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX3→partner) and Y-score (partner→PEX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR56A1 →	+0.012	+4.467	.005	.004	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
SKIN	KRTAP2-1 →	+0.258	+5.415	<.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.041	+4.614	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR56A1 by PEX3 expression — LARGE_INTESTINE

Explore this box plot interactively →