PEX3

Across TCGA cell cohorts, PEX3 mutation is significantly associated with the mutation status of many other genes, with 1,847 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PEX3-associated genes across cancer lineages are TULP2, ASIC2, and EEF1A1. Each is linked with PEX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX3-to-partner and partner-to-PEX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TULP2 grouped by PEX3-low versus PEX3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX3→partner) and Y-score (partner→PEX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TULP2 →	+5.824	+5.824	.002	.002	1	2
SKIN	ASIC2 →	+4.824	+5.392	.004	.004	1	2
SKIN	EEF1A1 →	+4.824	+5.392	.004	.004	1	2
SKIN	DNAJB8 →	+4.824	+5.392	.004	.004	1	2
SKIN	NXPE2 →	+4.239	+5.053	.007	.007	1	2
LARGE_INTESTINE	SYTL4 →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,847 associations by consensus.

TULP2 by PEX3 expression — SKIN

Explore this box plot interactively →